Trey Benson looks primed for Week 2 as the Arizona Cardinals host the Carolina Panthers. After outgaining starter James Conner on eight carries for 68 yards and playing 33% of snaps in Week 1, Benson’s role is trending upward in a backfield that could lean on explosive runs. The Panthers’ run defense allowed 143 rushing yards to Travis Etienne last week, signaling a favorable matchup for a two-back Arizona attack with Benson providing big-play upside. Startable in standard formats, Benson carries RB2 potential with weekly ceiling in a favorable script.

Expect Benson to contribute again alongside Conner, with a game plan that could tilt toward the ground game if Carolina can’t stack the box. Conner remains a reliable floor, but Benson’s burst adds a weekly upside that could swing lineups in Week 2. In deeper formats or DFS, Benson is a strong leverage option given the matchup and Arizona’s early momentum.

Jauan Jennings faces a Week 2 decision as he battles a shoulder injury that kept him sidelined at times in Week 1. With Brock Purdy out, the 49ers could lean on the run game and Christian McCaffrey, while Mac Jones starts at quarterback for the injury-plagued SF squad. If Jennings suits up, he could oscillate between a low-end flex and a risky upside play against a Saints secondary that's not impenetrable. If he sits, Ricky Pearsall and McCaffrey become the more dependable options, with Marquez Valdez-Scantling as a speculative depth piece.

The absence of George Kittle opens volume for others, but the QB switch may cap overall passing upside. Jennings’ value hinges on health and the Saints’ true pass defense; in a game likely dominated by the run, even a limited Jennings can carve out a usable role, though major upside isn’t guaranteed. Fantasy managers should weigh Jennings’ injury status heavily against the Week 2 risk/reward of this matchup.

Wan'Dale Robinson's Week 2 status casts a shadow over Giants-Cowboys. If active, he projects as a risky WR4/Flex in full-PPR after Week 1 volume, but his ankle injury creates clear risk on a tough Dallas matchup. If sidelined, Theo Johnson would absorb more targets and Malik Nabers becomes a deeper dart throw. New York sits as 4.5-point underdogs, and the game script could push heavy volume toward the Giants' passing game against a Cowboys secondary that allowed surprising WR production last season.